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Related Concept Videos

Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

49.0K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
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Biofilms01:29

Biofilms

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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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  11. Approaching Two Decades: Biomolecular Coronas And Bio-nano Interactions.
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Macromolecular And Materials Chemistry
  9. Nanochemistry
  11. Approaching Two Decades: Biomolecular Coronas And Bio-nano Interactions.

Related Experiment Video

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials
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Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

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Approaching Two Decades: Biomolecular Coronas and Bio-Nano Interactions.

Shiyao Li1, Christina Cortez-Jugo2, Yi Ju1

  • 1School of Science, RMIT University, Melbourne, Victoria 3000, Australia.

ACS Nano
|November 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The biomolecular corona, evolving from the protein corona, forms on nanoparticles in biological fluids. Understanding this corona is crucial for advancing nanomedicine design and targeting.

Keywords:
Biomolecular CoronaBio−Nano InteractionsLipid NanoparticlesProteins

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Area of Science:

  • Nanomedicine
  • Biomaterials Science
  • Surface Chemistry

Background:

  • The term "protein corona" has evolved to "biomolecular corona" (or "biocorona") to encompass all biomolecules forming on nanoparticles.
  • This corona influences nanoparticle interactions within biological systems.
  • Understanding the biocorona is essential for developing effective nanomedicines.

Purpose of the Study:

  • To review progress in biomolecular corona research.
  • To identify key research opportunities and challenges.
  • To discuss the role of advanced technologies in understanding the biocorona.

Main Methods:

  • Literature review and synthesis of current research.
  • Highlighting studies on nonprotein corona components and lipid nanoparticles.
  • Discussing the application of artificial intelligence and ex vivo models.

    • Main Results:

    • Significant progress has been made in understanding nonprotein corona components and lipid nanoparticles.
    • The role of the biocorona in endogenous organ targeting is increasingly recognized.
    • Advanced analytical techniques and models are improving biocorona characterization.

    Conclusions:

    • Further research is needed for improved characterization and standardization of biocorona analysis.
    • Artificial intelligence and ex vivo models offer promising avenues for deeper understanding.
    • Optimizing nanomedicine design relies on a comprehensive understanding of the biomolecular corona.