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Serum and urinary 5-hydroxyindolacetic acid, serotonin, chromogranin A, and NT-proBNP for the detection of carcinoid heart disease

  • 0Service d'Oncologie Médicale, Hospices Civils de Lyon, Centre d'Excellence ENETS, Lyon 69003, France.
European Journal of Endocrinology +

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November 27, 2024

|

November 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Serum 5-hydroxyindoleacetic acid (s5HIAA) shows high sensitivity and specificity for detecting carcinoid heart disease (CHD) in neuroendocrine tumour (NET) patients. This biomarker can serve as an effective pre-screening tool for CHD in NET populations.

Area Of Science

  • Oncology
  • Cardiology
  • Biomarker Research

Background

  • Carcinoid heart disease (CHD) is a complication of neuroendocrine tumours (NETs).
  • Accurate detection of CHD is crucial for managing NET patients.
  • Existing biomarkers for CHD detection require further evaluation.

Purpose Of The Study

  • To assess the efficacy of serum 5-hydroxyindoleacetic acid (s5HIAA) as a biomarker for CHD in NET patients.
  • To compare the performance of s5HIAA with urinary 5-HIAA (u5HIAA) in CHD detection.
  • To establish the diagnostic accuracy of s5HIAA for CHD.

Main Methods

  • An ancillary study of the French CrusoeNET cohort.
  • Inclusion of 138 patients with advanced/metastatic ileum or lung NET, or NET of unknown primary with clinical suspicion or elevated u5HIAA.
  • Serum samples collected between January 2021 and April 2022, with echocardiography performed by expert cardiologists.

Main Results

  • 19 out of 138 NET patients had confirmed CHD.
  • s5HIAA demonstrated a strong correlation with u5HIAA (ρ = 0.824, P < .0001).
  • s5HIAA showed high diagnostic accuracy for CHD (ROC curve = 0.85, P < .0001), with 84% sensitivity and 80% specificity at a threshold of 757 nmol/L.

Conclusions

  • Serum 5-hydroxyindoleacetic acid (s5HIAA) is a sensitive and specific biomarker for carcinoid heart disease (CHD) detection in neuroendocrine tumour (NET) patients.
  • s5HIAA can be utilized as a pre-screening tool for CHD, particularly in centers lacking systematic echocardiography.
  • This finding supports the integration of s5HIAA testing into routine NET patient management for early CHD identification.

Keywords:

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