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Synthesis and Regulation of Thyroid Hormones01:20

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[Occult thyroid dysfunction in outpatients with liver cirrhosis].

Nayeli Ortiz-Olvera1, Araceli Muñoz-Bautista1, Mario Molina-Ayala2

  • 1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Gastroenterología. Ciudad de México, México.

Revista Medica Del Instituto Mexicano Del Seguro Social
|November 27, 2024
PubMed
Summary

Thyroid dysfunction, particularly subclinical hypothyroidism, is common in liver cirrhosis patients. This condition occurs frequently in alcohol-induced cirrhosis and is independent of liver disease severity.

Keywords:
Cross-Sectional StudiesHepatitis CHepatitis, AutoimmuneHypothyroidismLiver Cirrhosis

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Area of Science:

  • Endocrinology
  • Hepatology
  • Internal Medicine

Context:

  • Liver cirrhosis (LC) is associated with various thyroid function alterations.
  • Screening for thyroid disease is crucial in patients with LC.

Purpose:

  • To screen for thyroid disease in adult patients diagnosed with liver cirrhosis.
  • To analyze thyroid dysfunction prevalence based on cirrhosis etiology, MELD score, and Child-Pugh class.

Summary:

  • A cross-sectional study measured thyroid-stimulating hormone (TSH) and free-tetraiodothyronine (T4) in 36% of LC patients, with subclinical hypothyroidism being the most frequent (34%).
  • Alcohol-induced cirrhosis showed the highest subclinical hypothyroidism rates (45%), and elevated TSH levels were noted in autoimmune and alcohol-induced cirrhosis.
  • No correlation was found between thyroid hormones and age, MELD, or C-P scores, indicating occult thyroid dysfunction is prevalent regardless of liver reserve.

Impact:

  • Highlights the high prevalence of occult thyroid dysfunction in liver cirrhosis patients.
  • Identifies alcohol-induced cirrhosis as a significant risk factor for subclinical hypothyroidism.
  • Suggests the need for longitudinal studies to determine the clinical impact of subclinical hypothyroidism on cirrhosis progression.