Related Experiment Video
Updated: Jun 6, 2025
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Does Atopic Dermatitis Increase the Risk of Inflammatory Bowel Disease? A Meta-Analysis of Data from 61 Million
1Department of Dermatology, Affiliated Haikou Hospital, Xiangya School Central South University and Haikou Municipal Municipal People's Hospital, Haikou, China.
Introduction:
This review aimed to examine if atopic dermatitis (AD) led to an increased risk of inflammatory bowel disease (IBD) by collating data from longitudinal studies.
Methods:
Cohort and case-control studies examining the risk of IBD, Crohn's disease (CD), or ulcerative colitis (UC) due to exposure to AD were included in this review. Articles were searched on PubMed, CENTRAL, Embase, Scopus, and Web of Science electronic repositories up to 2nd October 2024.
Results:
Eight retrospective cohort studies with 61,190,816 participants were included. The meta-analysis found that AD was a significant risk factor for IBD (OR: 1.37; 95% CI: 1.31, 1.43). No statistical heterogeneity was noted. Pooled analysis showed that exposure to AD was a significant risk factor for both CD (OR: 1.51; 95% CI: 1.31, 1.76) and UC (OR: 1.33; 95% CI: 1.13, 1.56). Both meta-analyses had high inter-study heterogeneity with I2 = 83% and I2 = 89%, respectively. Results remained significant on sensitivity analysis.
Conclusion:
Our study shows an association between AD and IBD. The association was persistent for both CD and UC. Given the small increase in risk of IBD in AD, its clinical relevance may be questionable.
More Related Videos
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
07:34Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...