The impact of immune-related adverse events on survival outcomes in a racially diverse population, with a focus on non-Hispanic Black patients
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View abstract on PubMed
Summary
This summary is machine-generated.Immune-related adverse events (irAEs) in non-small cell lung cancer (NSCLC) patients are linked to better survival, regardless of race. This study found similar irAE incidence across racial groups, confirming their positive impact on outcomes.
Area Of Science
- Oncology
- Immunotherapy
- Health Disparities
Background
- Immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICIs) correlate with improved survival in non-small cell lung cancer (NSCLC).
- The association between irAEs and survival outcomes across diverse racial and ethnic groups remains understudied.
- Safety net hospitals serve diverse patient populations, making them crucial for investigating health disparities in cancer treatment.
Purpose Of The Study
- To investigate the association between irAE development and treatment outcomes in a racially diverse NSCLC patient cohort.
- To determine if the incidence of irAEs differs across racial subgroups.
- To assess if the survival benefits associated with irAEs are consistent across different races and ethnicities.
Main Methods
- Retrospective chart review of advanced NSCLC patients treated with ICIs between 2015 and 2020.
- Logistic regression to compare irAE incidence across racial subgroups.
- Cox regression to evaluate the association between irAEs and treatment outcomes, including progression-free survival (PFS).
Main Results
- Of 138 NSCLC patients, 50% were non-Hispanic Black (NHB). Overall irAE incidence was 28%, with no significant difference between NHB and other racial groups.
- Females and patients with Medicaid/MassHealth insurance showed a higher incidence of irAEs.
- Patients experiencing irAEs had a significantly lower risk of disease progression (HR 0.46) and similar PFS benefit across racial groups.
Conclusions
- The incidence of irAEs in NHB NSCLC patients is comparable to other racial groups.
- Development of irAEs is associated with significantly improved survival outcomes in NSCLC patients.
- The positive association between irAEs and survival is independent of race and ethnicity, highlighting the need for unbiased treatment recommendations.
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