Related Experiment Video

Updated: Jul 3, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

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Discrepancy of Hans' criteria for clonally related nodal and pericardiac fluid diffuse large B-cell lymphoma with

Toshiki Terao1,2, Yumiko Sato3, Yoshiaki Kuroda4

  • 1Department of Hematology, NHO Iwakuni Clinical Center, Iwakuni, Japan.

Journal of Clinical and Experimental Hematopathology : JCEH
|November 27, 2024
PubMed

Insights

This case study identifies two distinct large B-cell lymphomas in a patient, one in the pericardial fluid and another in a lymph node. Genetic analysis revealed a clonal relationship and a shared MYD88 mutation, suggesting a common origin despite differing cell-of-origin classifications.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Large B-cell lymphoma (LBCL) is a heterogeneous group of lymphoid malignancies.
  • Accurate cell-of-origin classification is crucial for prognosis and treatment selection.
  • Discrepancies in classification can arise from different diagnostic criteria.

Keywords:
CD10Hans’ criteriaMCD typeMYD88 L265P mutationdiffuse large B-cell lymphoma

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