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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
Bupropion-induced pancytopenia
Jowon L Kim1, David Chercover2, Hamid Masoudi2
1Division of Hematology, The University of British Columbia, Vancouver, British Columbia, Canada jowonlaura.kim@ubc.ca.
Abstract:
Bupropion is not a well established cause of medication-induced pancytopenia. In this report, we discuss a case of agranulocytosis, normocytic anemia and severe thrombocytopenia, with concurrent drug-induced rash within 3 weeks of bupropion initiation. Bone marrow biopsy demonstrated hypocellularity <10% without dysplastic features or increase in blast cells. Other causes of cytopenias, including infections, nutritional deficiencies, autoimmune disorders, liver/renal disease, thrombotic microangiopathy, primary bone marrow disorders and secondary marrow infiltrative diseases were ruled out. Pancytopenia resolved after 1 week of bupropion discontinuation and supportive care.
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