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Multifunctional Adhesive Hydrogels: From Design to Biomedical Applications.

Shaoxin Tang1,2, Keru Feng1,2, Rui Yang1,2

  • 1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.

Advanced Healthcare Materials
|November 28, 2024
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Summary

Adhesive hydrogels mimic the extracellular matrix for advanced biomedical uses. This review details design strategies and functionalities for tissue repair, drug delivery, and sensors.

Keywords:
adhesion mechanismadhesive hydrogelbiomedical applicationmultifunctional hydrogeltissue adhesion

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Adhesive hydrogels possess extracellular matrix-like structures, biocompatibility, controlled degradation, and tunable mechanical properties.
  • These materials exhibit strong adhesion and can be engineered for specific biomedical applications like tissue engineering, biosensors, and drug delivery.

Purpose of the Study:

  • To review advancements in adhesive hydrogel design strategies for biomedical applications.
  • To discuss the functionalities and applications of these hydrogels, including tissue repair, drug delivery, medical devices, and wearable sensors.
  • To highlight current challenges and future trends in adhesive hydrogel research.

Main Methods:

  • Review of chemical bond-based design strategies for tissue adhesion (covalent and non-covalent interactions).
  • Discussion of imparted functionalities: stretchability, toughness, responsiveness, anti-freezing/heating, conductivity, antibacterial, and hemostatic properties.
  • Analysis of recent biomedical applications in tissue repair, drug delivery, medical devices, and wearable sensors.

Main Results:

  • Adhesive hydrogels can be designed using various chemical bond strategies to achieve specific properties.
  • These hydrogels demonstrate diverse functionalities crucial for advanced biomedical applications.
  • Significant progress has been made in applying these materials to tissue repair, drug delivery, and wearable sensors.

Conclusions:

  • Adhesive hydrogels offer versatile platforms for biomedical innovation due to their tunable properties and adhesion.
  • Further research into design strategies and functionalities will expand their therapeutic and diagnostic potential.
  • Addressing current challenges is key to unlocking the full future potential of adhesive hydrogels in medicine.