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The Relationship Between Preoperative Vitamin D Levels and Keloid Recurrence.
Da Woon Lee1, Daihun Kang2, Boram Ha3
1Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
Journal of Cosmetic Dermatology
|November 28, 2024
Summary
Preoperative vitamin D levels do not predict keloid recurrence. Older age, however, was linked to a lower risk of keloid recurrence in this Korean population study.
Area of Science:
- Dermatology
- Biochemistry
Background:
- Keloids involve excessive collagen deposition and frequently recur post-treatment.
- Investigating predictive factors for keloid recurrence is crucial for effective management.
Purpose of the Study:
- To examine the relationship between preoperative serum vitamin D levels and keloid recurrence.
- To identify predictors of keloid recurrence in a Korean population.
Main Methods:
- Retrospective analysis of 160 patients undergoing keloid excision.
- Measurement of preoperative serum 25(OH) vitamin D and 1,25(OH)2 vitamin D.
- Hierarchical logistic regression analysis to assess recurrence predictors.
Main Results:
- Older age was significantly associated with a reduced risk of keloid recurrence (OR: 0.934, p=0.009).
- No significant association was found between preoperative vitamin D levels (25(OH) or 1,25(OH)2) and keloid recurrence.
Conclusions:
- Preoperative vitamin D levels do not appear to predict keloid recurrence in this cohort.
- Age is a significant predictor of keloid recurrence.
- Further research is needed to understand the complex factors influencing keloid formation.
