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[Clinical experiences with an antimycotic foam preparation with added prednisolone (Nystacorton foam)]
Insights
A new foam preparation effectively treated Candida infections in infants and children, clearing severe skin lesions within 13 days. Follow-up with a non-medicated cream aided recovery.
Area of Science:
- Dermatology
- Mycology
- Pediatrics
Context:
- Candida infections commonly affect infants and children in diaper-associated areas.
- Skin infections in pediatric patients often require effective and safe treatment options.
Purpose:
- To evaluate the efficacy of a novel foam preparation containing nystatin, chlorhexidine, and prednisolone for treating pediatric Candida skin infections.
Summary:
- Twenty-five pediatric patients with confirmed Candida infections were treated with a combination foam. All cases, including severe lesions, resolved within 13 days.
- The foam preparation demonstrated high efficacy in clearing superficial fungal infections.
- A subsequent non-medicated cream (Excipial Cream) was beneficial during the resolution phase.
Impact:
- This study highlights a promising therapeutic option for pediatric superficial fungal infections.
- The combined foam offers a potentially rapid and effective treatment for Candida skin infections in children.
- Findings support the use of combination therapy for managing challenging pediatric dermatological conditions.
Abstract:
Twenty-five infants and children with Candida infections in the perianal, genital and inguinal areas and on the skin normally covered by the napkin or diaper, confirmed by culture tests and microscopy, were treated with a new combined foam preparation containing the active substances nystatin, chlorhexidine and prednisolone. Even partially very severe lesions with multiple, satellitelike colonies on the trunk, extremities and neck were, without exception, cured within a maximum of 13 days. After disappearing of the exudative stage, intermittent treatment with a rather more greasy excipient (Excipial Cream) containing no active substance, has proved beneficial.