Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Machine learning assisted predicting and engineering specific surface area and total pore volume of biochar.

Bioresource technology·2022

Same author

Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder.

BMC psychiatry·2022

Same author

The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice.

International journal of biological macromolecules·2022

Same author

Effects of an Intermittent Fasting 5:2 Plus Program on Body Weight in Chinese Adults with Overweight or Obesity: A Pilot Study.

Nutrients·2022

Same author

Accessibility of essential anticancer medicines for children in the Sichuan Province of China.

Frontiers in public health·2022

Same author

The delivery of nanoparticles improves the pharmacokinetic properties of celecoxib to open a therapeutic window for oral administration of insoluble drugs.

Biomedical chromatography : BMC·2022

Search research articles

Related Experiment Video

Updated: Jun 6, 2025

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

A diffusion tensor imaging-based multidimensional study of brain structural changes after long-term high-altitude

Ning Liu¹, Li Feng¹, Shuangwei Chai²

¹Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), Chengdu, Sichuan, China.

Frontiers in Physiology

|November 28, 2024

Summary

Long-term high-altitude exposure alters brain structure, affecting sleep, emotion, and cognition. This study reveals white matter damage in the corpus callosum, potentially compensated by adaptive mechanisms.

Keywords:

DTI TBSS cognitive function high-altitude long-term adaptation

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Related Experiment Videos

Last Updated: Jun 6, 2025

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Area of Science:

Neuroscience
High-altitude physiology
Cognitive science

Background:

Limited research exists on long-term high-altitude adaptation's effects on brain structure and cognitive function.
Previous studies show inconsistent results regarding high-altitude environments and their impact on the brain.
The pathophysiological mechanisms linking high-altitude exposure to cognitive changes remain unclear.

Purpose of the Study:

To investigate white matter fiber tract damage using diffusion tensor imaging (DTI) in individuals adapted to high altitudes.
To explore correlations between brain structural abnormalities and cognitive function in high-altitude dwellers.
To compare brain structure and cognitive function between high-altitude and sea-level populations.

Main Methods:

Employed diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) to analyze white matter integrity.
Assessed cognitive function using tests like DST-Backwards, MoCA, and MMSE.
Evaluated emotional state and sleep quality using PSQI, SDS, SAS, PHQ-9, and GAD-7, with statistical analysis including t-tests and correlation methods.

Main Results:

High-altitude residents exhibited higher scores for sleep disturbances, anxiety, and depression, alongside lower scores in cognitive tests.
Reduced fractional anisotropy (FA) in the body of the corpus callosum was observed in the high-altitude group.
A negative correlation between corpus callosum FA and logical memory was found in the plain group, but not in the high-altitude group.

Conclusions:

Long-term high-altitude exposure induces changes in sleep, emotion, and cognition, with microstructural white matter damage in the corpus callosum.
The corpus callosum, crucial for logical memory, shows irreversible microstructural damage.
The absence of significant logical memory impairment in the high-altitude population suggests potential adaptive compensation mechanisms.