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Crotonylation modification and its role in diseases
Yi Guo1, Junqin Li1, Kaiming Zhang1
1Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Central Hospital of Shanxi Medical University, Taiyuan, China.
Frontiers in Molecular Biosciences
|November 28, 2024
Summary
Protein lysine crotonylation, a key acylation modification, regulates biological processes and is linked to reproduction, development, and disease. Understanding its enzymes and functions offers new therapeutic strategies.
Area of Science:
- Biochemistry
- Molecular Biology
- Epigenetics
Background:
- Protein lysine crotonylation is a post-translational modification regulating biological processes.
- Thousands of crotonylation sites in proteins have been identified since its discovery in 2011.
- Crotonylation is a conserved process involving "writer", "eraser", and "reader" enzymes.
Purpose of the Study:
- To review enzyme systems, biological functions, and disease relevance of protein lysine crotonylation.
- To highlight recent advancements in crotonylation research.
- To propose crotonylation as a target for disease intervention.
Main Methods:
- Literature review of crotonylation research.
- Analysis of enzyme systems involved in crotonylation.
- Examination of biological functions and disease associations.
Main Results:
- Crotonylation is a conserved regulatory mechanism.
- Aberrant crotonylation is implicated in various diseases.
- Crotonylation plays significant roles in reproduction and development.
Conclusions:
- Protein lysine crotonylation is a crucial regulatory modification with broad biological implications.
- Further research into crotonylation pathways can lead to novel therapeutic strategies.
- Understanding crotonylation offers new avenues for disease treatment.
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