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A novel platelets-related gene signature for predicting prognosis, immune features and drug sensitivity in gastric cancer

  • 0Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Frontiers in Immunology +

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November 28, 2024

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November 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed a ten-gene signature to predict gastric cancer (GC) outcomes. The signature effectively forecasts prognosis and potential treatment responses in GC patients.

Area Of Science

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background

  • Platelets play a dynamic role in tumor development, but their predictive value in gastric cancer (GC) is under-researched.
  • Limited understanding exists regarding the specific functions of platelets in GC progression.

Purpose Of The Study

  • To create a predictive gene signature related to platelets for GC.
  • To explore the prognostic and therapeutic implications of this signature in GC.

Main Methods

  • Utilized TCGA transcriptome data from 378 GC patients.
  • Constructed a risk model using LASSO regression on prognostic platelet-related genes.
  • Validated the model in independent cohorts and analyzed tumor microenvironment (TME) and drug sensitivity.

Main Results

  • A ten-gene signature (SERPINE1, ANXA5, DGKQ, PTPN6, F5, DGKB, PCDH7, GNG11, APOA1, TF) was established.
  • The signature accurately predicted overall survival (OS) in GC patients (AUCs up to 0.763 for the nomogram).
  • High-risk patients exhibited an immunosuppressive TME and sensitivity to specific drugs (thalidomide, MK-0752, BRD-K17060750).

Conclusions

  • The identified platelet-related gene signature serves as a valuable tool for predicting prognosis in GC.
  • This signature also offers insights into potential therapeutic strategies for gastric cancer.

Keywords: