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Updated: May 5, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
Published on: December 21, 2018
Case Report and Literature Review: A Severe Case of Blast-Related Traumatic Brain Injury
Wei Lun Lee1, Azmi Alias1, Mei Sin Lim1
1Neurosurgery Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Abstract:
Blast-related traumatic brain injuries (bTBIs), once considered the signature wound of wars, have increasingly affected civilian populations due to the rise in terrorist attacks and industrial accidents. These injuries are complex, resulting from a combination of primary blast effects, secondary projectiles, tertiary impacts, and quaternary injuries from burns and toxic gas inhalation. Understanding the clinical presentation, management strategies, and outcomes of bTBIs is essential for enhancing patient care and improving prognosis. We report a case of industrial-related severe bTBI with opened depressed skull fracture and intracranial hematoma. The patient underwent decompressive craniectomy and evacuation of clot but postoperatively had a stormy recovery and multiple complications. He eventually succumbed due to his complications. This underscores the complexity of bTBIs and highlights the importance of a multidisciplinary approach in the management of bTBIs. Further research is needed to optimize treatment protocols and rehabilitation strategies for individuals with bTBIs.
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