Role of disulfide death in cancer (Review)
Xue Li1, Danxia Zhu1
1Oncology Department, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China.
Abstract:
The research field of regulated cell death is growing extensively. Following the recognition of ferroptosis, other unique and distinct forms of regulated cell death, including cuproptosis and disulfide death, have been identified. Disulfide death occurs due to the abnormal accumulation of disulfides within cells in environments lacking glucose, leading to contraction of the actin cytoskeleton, which ultimately triggers various signaling pathways and cell death. The induction of disulfide death in the treatment of cancer may exhibit significant therapeutic potential. Therefore, in the present review, a comprehensive and critical analysis of the current understanding of the molecular mechanisms and regulatory networks of disulfide death is presented. In addition, the potential physiological functions of disulfide death in tumor suppression and immune surveillance as well as its pathological roles and therapeutic potential are described. The core focus areas for future research into this form of cell death are also explored. Given the current lack of extensive clinical findings and well-defined key concepts, these may be regarded as pivotal points of interest in future studies.
Insights
Disulfide death, a novel cell death form, arises from disulfide buildup in glucose-deficient conditions. This process shows promise for cancer therapy and warrants further research into its mechanisms and applications.
Area of Science:
- Cellular Biology
- Molecular Mechanisms of Cell Death
Background:
- Regulated cell death research is expanding, with ferroptosis, cuproptosis, and disulfide death emerging as distinct forms.
- Disulfide death is triggered by abnormal disulfide accumulation in glucose-deprived environments, impacting the actin cytoskeleton and signaling pathways.
Purpose of the Study:
- To provide a comprehensive analysis of disulfide death's molecular mechanisms and regulatory networks.
- To explore the physiological functions, pathological roles, and therapeutic potential of disulfide death, particularly in cancer treatment.
Main Methods:
- Literature review and critical analysis of existing research on disulfide death.
- Synthesis of current knowledge on molecular pathways and cellular responses involved in disulfide death.
Main Results:
- Disulfide death involves actin cytoskeleton contraction and subsequent signaling pathway activation.
- Potential roles in tumor suppression and immune surveillance are suggested, alongside therapeutic applications in oncology.
Conclusions:
- Disulfide death presents significant therapeutic potential for cancer treatment.
- Further research is crucial to define key concepts and gather clinical findings for this emerging cell death pathway.
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