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Late-Onset Vitiligo: Epidemiology, Clinical Characteristics, and Management Strategies
Zahbi Hasan1, Yashdeep Singh Pathania1
1Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Rajkot, Gujarat, India.
Journal of Cosmetic Dermatology
|November 28, 2024
Summary
Late-onset vitiligo (LOV) presents unique challenges. This review highlights its distinct epidemiology, clinical features, and treatment responses, emphasizing the need for personalized patient care.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Epidemiology
Background:
- Late-onset vitiligo (LOV), defined as onset at age 30+, poses diagnostic and management difficulties.
- LOV arises from a complex interaction of genetic, environmental, and societal factors.
Purpose of the Study:
- To review the epidemiology and clinical characteristics of LOV.
- To analyze treatment outcomes for LOV.
- To improve diagnostic precision and management strategies for LOV.
Main Methods:
- A systematic literature search was performed using PRISMA guidelines.
- Databases searched included PubMed and EMBASE.
- Studies involving adults diagnosed with LOV were included for data extraction.
Main Results:
- Five studies with 1099 patients were analyzed.
- LOV prevalence was 6.5%-14.7%, with onset in the mid-to-late 50s.
- Vitiligo vulgaris was most common, with leukotrichia and Koebner phenomenon. Comorbidities like diabetes and thyroid disease were noted. Combination and phototherapy showed promise.
Conclusions:
- Late-onset vitiligo exhibits distinct clinical and epidemiological features compared to early-onset forms.
- Treatment responses in LOV necessitate tailored management approaches.
- Personalized care is crucial for effectively managing LOV.
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