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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Dual Inert C-H Bond Site-Selective Activations Enabled by Pd/Norbornene-Mediated Cascade Cyclization toward
Li Wei1, Fang Xun1,2, Xiaojuan Chen2
1College of Chemistry and Materials, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China.
Abstract:
A Pd/norbornene-mediated three-component modular one-step reaction facilitated by dual C-H bond activation and cascade cyclization is reported. This procedure uses norbornene as a catalyst in the Catellani-type reaction and as an alkylating building block to accomplish the dual unactivated C-H bond functionalization protocol, which results in the production of polyheterocyclic eight-membered sulfoximines with an indene-fused moiety. This mild, scalable protocol's wide substrate range makes it ideal for site-selective dual C-H functionalization at the highly chemoselective aryl sites.
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