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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

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Degradation and Fatigue Behavior of 3D-Printed Bioresorbable Tracheal Splints.

Jenna M Wahbeh^1,2, John Lama^1,2, Sang-Hyun Park^1,3

¹J. Vernon Luck, Sr., M.D. Orthopaedic Research Center, Luskin Orthopaedic Institute for Children in Alliance With UCLA, Los Angeles, California, USA.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|November 28, 2024

Summary

This study evaluated novel 3D-printed splints for infantile tracheobronchomalacia (TBM). The bioresorbable splints showed promising flexibility and strength, supporting tracheal collapse prevention in simulations.

Keywords:

3D‐printing Tracheobronchomalacia degradation fatigue splint

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Area of Science:

Biomedical Engineering
Materials Science
Pediatric Surgery

Background:

Infantile tracheobronchomalacia (TBM) often requires invasive surgery and rigid implants.
A novel, flexible, and bioresorbable 3D-printed splint offers a potential alternative.

Purpose of the Study:

To evaluate the structural stiffness and failure modes of two sizes of a novel bioresorbable 3D-printed splint.
To assess splint performance under simulated breathing and physiological degradation conditions.

Main Methods:

Two splint thicknesses (2mm and 3mm) were tested in simulated breathing and static soaking conditions (PBS and NaOH).
Cyclic loading simulated breathing for 7.5 to 30 million cycles.
Tensile and compressive strengths were evaluated after degradation.

Main Results:

Splints degraded more significantly under simulated breathing than static soaking.
Cyclic loading led to earlier splint failure than intended.
Static degradation increased splint flexibility over time, with minimal differences between thicknesses.
Splints withstood tensile forces, preventing tracheal collapse.

Conclusions:

The bioresorbable 3D-printed splints demonstrate potential for treating infantile TBM.
Degradation increases flexibility, accommodating infant tracheal growth.
These splints eliminate the need for removal surgery, offering a less invasive treatment option.