Can the free/total psa ratio predict undetected intraductal carcinoma and cribriform pattern at biopsy?
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View abstract on PubMed
Summary
This summary is machine-generated.Free-to-total PSA ratio (FPSAR) does not reliably identify aggressive prostate cancer variants like intraductal carcinoma (IDC) or cribriform pattern (Crib) during biopsy. Further research is needed to find better biomarkers for these high-risk prostate cancer types.
Area Of Science
- Urology
- Oncology
- Pathology
Background
- Intraductal carcinoma (IDC) and cribriform pattern (Crib) are aggressive prostate cancer variants associated with poor outcomes.
- Accurate identification of IDC/Crib at biopsy is crucial for treatment planning.
Purpose Of The Study
- To evaluate the predictive value of the Free-to-total PSA ratio (FPSAR) in detecting missed IDC/Crib at prostate biopsy.
- To compare FPSAR's accuracy against final radical prostatectomy (RP) findings.
Main Methods
- Retrospective analysis of 639 patients undergoing RP between 2015-2022.
- Multivariate logistic regression to identify predictors of false-negative biopsies for IDC/Crib.
- Chi-squared and Kruskal-Wallis tests to assess associations with FPSAR.
Main Results
- FPSAR (≥0.10) was not an independent predictor of false-negative IDC/Crib biopsies (p > 0.05).
- Factors associated with lower odds of false-negative biopsies included higher percentage of pattern 4 (≥10%), higher Gleason score (grade group 4/5), and a higher percentage of positive biopsy cores (≥33%).
Conclusions
- FPSAR is not a reliable biomarker for identifying IDC/Crib status during prostate biopsy.
- Additional research is necessary to discover effective biomarkers for diagnosing aggressive prostate cancer variants.
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