Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Dementia l: Introduction01:22

Dementia l: Introduction

31
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
31

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atypical Atypical MECP2-Related Rett Syndrome Presenting with Movement Disorders- Predominating Phenotype.

Movement disorders clinical practice·2026
Same author

Integrating Long-Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia.

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

Expanding the Allelic and Clinical Heterogeneity of Movement Disorders Linked to Defects of Mitochondrial Adenosine Triphosphate Synthase.

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

Prevalence and Clinical Characteristics of the LRRK2 p.L1795F Variant in Central Europeans with Early-Onset and Familial Parkinson's Disease.

Movement disorders clinical practice·2025
Same author

Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia.

Brain : a journal of neurology·2025
Same author

Myoclonus and Dystonia as Recurrent Presenting Features in Patients with the SCA21-Associated <i>TMEM240</i> p.Pro170Leu Variant.

Tremor and other hyperkinetic movements (New York, N.Y.)·2024

Related Experiment Video

Updated: Apr 28, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K

The three clap test: a window into cognitive and frontal lobe dysfunction.

Zuzana Brežná1, Katarína Ďurčová Typčuková1, Ján Necpál2,3

  • 1Parkinsonism and Movement Disorders Treatment Center, Zvolen Hospital, Zvolen, Slovakia.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|November 28, 2024
PubMed
Summary

The three clap test (TCT) reveals the applause sign (AS), indicating cognitive and frontal lobe dysfunction. This bedside test helps differentiate neurological conditions like progressive supranuclear palsy (PSP) and Parkinson

Keywords:
Applause signCognitive dysfunctionFrontal lobe dysfunctionJumping the gun signThree clap testTriple test

More Related Videos

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.3K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.0K

Related Experiment Videos

Last Updated: Apr 28, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

13.7K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.3K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.0K

Area of Science:

  • Neurology
  • Cognitive Neuroscience

Background:

  • The three clap test (TCT) elicits the applause sign (AS), characterized by more than three claps after instruction.
  • AS was initially used to distinguish progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and frontotemporal dementia (FTD).
  • AS is also observed in PD, Alzheimer's disease, and other conditions, reflecting stopping impulsivity and frontal lobe dysfunction.

Purpose of the Study:

  • To review the clinical aspects and pathophysiology of signs elicited by the TCT.
  • To discuss the utility of the TCT in routine clinical practice.

Main Methods:

  • Literature review of clinical studies and pathophysiological research related to the TCT and its associated signs.
  • Analysis of the diagnostic value of the TCT in various neurological and cognitive disorders.

Main Results:

  • The TCT can elicit the AS (stopping impulsivity), non-applause sign (apathy in behavioral variant FTD), and jumping the gun sign (waiting impulsivity in PSP).
  • These signs are indicative of cognitive and frontal lobe dysfunction, with varying prevalence across different diseases.
  • The TCT offers a simple bedside method for assessing these specific neurological signs.

Conclusions:

  • The TCT is a valuable bedside tool for identifying specific neurological signs related to impulsivity and cognitive dysfunction.
  • Understanding the TCT signs aids in the differential diagnosis of neurodegenerative diseases.
  • Further integration of the TCT into clinical practice may enhance diagnostic capabilities for frontal lobe and cognitive impairments.