A reactive oxygen species-related signature predicts the prognosis and immunosuppressive microenvironment in gliomas
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View abstract on PubMed
Summary
This summary is machine-generated.A novel 19-gene signature linked to reactive oxygen species (ROS) effectively predicts glioma patient prognosis. High ROS levels correlate with an immunosuppressive tumor microenvironment, impacting treatment strategies.
Area Of Science
- Oncology
- Molecular Biology
- Immunology
Background
- Intracellular redox homeostasis is vital for cellular functions.
- Reactive oxygen species (ROS) are key players in redox processes, influencing cell survival and tumor development.
- Understanding ROS's role in cancer is critical for developing new therapeutic strategies.
Purpose Of The Study
- To establish a gene signature associated with ROS to investigate its impact on glioma prognosis.
- To explore the relationship between ROS and the tumor immune microenvironment in gliomas.
Main Methods
- Comprehensive analysis of ROS-related gene expression profiles in glioma datasets.
- Development and validation of a 19-gene ROS-related signature for prognostic prediction.
- Functional analysis to assess the association between ROS levels and immune cell infiltration.
Main Results
- The ROS-related gene expression profile distinguished patients into distinct prognostic groups.
- The 19-gene signature accurately predicted prognosis in both training and validation cohorts.
- High ROS levels were associated with an upregulation of immune checkpoints and M2-type markers, suggesting an immunosuppressive tumor microenvironment.
Conclusions
- The ROS-related gene signature serves as an independent prognostic factor for gliomas.
- ROS may exert immunosuppressive effects within the glioma tumor microenvironment, offering potential therapeutic targets.
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