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Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Related Experiment Video

Updated: May 5, 2026

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Recent developments in olfactory neuroblastoma research.

Anthony Ghanem¹, John B Finlay^1,2, David W Jang¹

¹Department of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine.

Current Opinion in Otolaryngology & Head and Neck Surgery

|November 28, 2024

Summary

This summary is machine-generated.

Olfactory neuroblastoma (ONB) research shows advances in genomic profiling and targeted therapies like PD-L1 inhibitors. New mouse models aid treatment strategies for this rare cancer.

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The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

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Last Updated: May 5, 2026

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

Published on: October 30, 2014

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Area of Science:

Oncology
Genetics
Molecular Biology

Background:

Olfactory neuroblastoma (ONB) is a rare malignancy of olfactory neuroepithelial cells.
Its uncommon nature and complex presentation pose diagnostic and therapeutic challenges.

Purpose of the Study:

To review recent findings and treatment approaches for olfactory neuroblastoma.
To highlight advancements for improving clinical practice and research in ONB.

Main Methods:

Comprehensive literature review of recent advancements in ONB.
Analysis of genomic profiling, molecular classification, and targeted therapies.
Evaluation of genetically engineered mouse models for ONB research.

Main Results:

Significant progress in genomic profiling and molecular classification of ONB.
Emerging targeted therapies include somatostatin analogs and PD-L1 inhibitors.
Genetically engineered mouse models reveal ONB similarities to small cell lung cancer, informing new strategies.

Conclusions:

Advanced imaging and genomic profiling enhance diagnostic accuracy for personalized ONB treatments.
Genetically engineered mouse models and collaborative efforts are crucial for research and molecular testing standardization.
Integrating advanced imaging, genomic profiling, and targeted therapies promises improved patient outcomes for ONB.