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Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression

  • 0Department of Pharmacology, Nantong University, Nantong 226001, Jiangsu, China.
Biochemical Pharmacology +

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November 28, 2024

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November 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This review explores how the vasopressin V1B receptor (V1B R) influences the stress response in depression. V1B R antagonists show promise for treating depression by regulating the hypothalamic-pituitary-adrenal (HPA) axis.

Area Of Science

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background

  • Depression is a recurrent psychiatric disorder linked to heritable and environmental factors.
  • Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in adult depression.
  • Arginine vasopressin (AVP) regulates stress and anxiety, and is involved in various disorders.

Purpose Of The Study

  • To review and integrate clinical and preclinical literature on the role of the V1B receptor (V1B R) in depression.
  • To emphasize the effects of V1B R antagonists in attenuating HPA axis hyperactivity.
  • To discuss HPA axis-targeted therapies for depression.

Main Methods

  • Literature review of clinical and preclinical studies.
  • Integration of data on V1B R function and depression.
  • Focus on V1B R antagonists and HPA axis modulation.

Main Results

  • The V1B receptor plays a pivotal role in HPA axis abnormalities associated with depression.
  • V1B R antagonists have demonstrated antidepressant activity in animal models.
  • These antagonists reduce plasma stress hormone levels.

Conclusions

  • Understanding V1B R mechanisms is crucial for developing novel depression therapies.
  • Targeting the HPA axis via V1B R offers a potential therapeutic strategy.
  • Further research into V1B R function can improve treatment for non-responsive depression patients.

Keywords:

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