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miRNA signatures affecting the survival outcome in distant metastasis of triple-negative breast cancer

  • 0Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar 249 405, India.
Biochemical Pharmacology +

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November 28, 2024

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November 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Triple-negative breast cancer (TNBC) has poor survival outcomes, especially when metastatic. MicroRNAs (miRNAs) show promise in treating TNBC by potentially reducing metastasis and improving patient survival.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Triple-negative breast cancer (TNBC) accounts for 10-15% of breast cancers.
  • TNBC is characterized by high invasiveness, distant metastasis, and poor survival rates due to lack of specific biomarkers.
  • Tumor recurrence is frequent in TNBC, with metastatic patients facing worse prognoses than non-metastatic ones.

Purpose Of The Study

  • To review varying survival outcomes in metastatic versus non-metastatic TNBC.
  • To emphasize the therapeutic and prognostic potential of microRNAs (miRNAs) in TNBC.
  • To explore how miRNAs can improve survival by inhibiting distant metastasis.

Main Methods

  • Literature review focusing on TNBC, metastasis, and microRNA functions.
  • Analysis of clinico-pathological data and survival outcomes in TNBC patients.
  • Examination of miRNA roles as oncogenes or tumor suppressors in the TNBC microenvironment.

Main Results

  • TNBC patients with distant metastasis exhibit significantly poorer survival outcomes.
  • MicroRNAs demonstrate pleiotropic effects, acting as oncogenes or tumor suppressors.
  • miRNAs modulate target gene expression within the TNBC tumor microenvironment.

Conclusions

  • MicroRNAs hold significant preclinical and clinical potential for treating both metastatic and non-metastatic TNBC.
  • Targeting miRNAs could improve survival outcomes by reducing metastasis to organs like the lung, bone, and brain.
  • Understanding miRNA roles is crucial for developing novel therapeutic strategies to combat TNBC progression and recurrence.

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