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Exploring the association between BDNF related signaling pathways and depression: A literature review

Yuchen Fan1, Xinchi Luan2, Xuezhe Wang3

  • 1Interventional Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China; Qingdao medical college, Qingdao University, Qingdao, Shandong, China.

Brain Research Bulletin
|November 28, 2024
PubMed

Insights

Brain-derived neurotrophic factor (BDNF) pathways are crucial in depression. Understanding how BDNF interacts with its receptors, TrkB and p75NTR, offers new insights for developing effective depression treatments.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background:

  • Depression is a widespread mental health disorder with unclear pathogenesis.
  • Brain-derived neurotrophic factor (BDNF) plays a role in depression.
  • BDNF acts on tyrosine kinase receptor (TrkB) and p75 neurotrophin receptor (p75NTR).

Purpose of the Study:

  • To review and summarize BDNF-related signaling pathways in depression.
  • To classify these pathways based on receptors and molecules.
  • To provide insights for future depression treatment strategies.

Main Methods:

  • Literature review of studies on BDNF and depression.
  • Analysis of BDNF's downstream signaling pathways.
  • Classification of pathways by receptor interactions (TrkB, p75NTR).

Main Results:

  • BDNF signaling pathways are critical in depression pathophysiology.
  • Interactions between BDNF and its receptors influence depression.
  • Specific pathways affected by BDNF-TrkB and BDNF-p75NTR interactions are identified.

Conclusions:

  • BDNF-related pathways are key targets for depression treatment.
  • Understanding BDNF receptor interactions can guide therapeutic development.
  • Further research into these pathways may lead to novel antidepressant strategies.
Keywords:
Brain-derived neurotrophic factorDepressionSignaling pathwayTrkBp75NTR

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