JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Postoperative skeletal muscle loss as a prognostic indicator of clinical outcomes in patients with gastric cancer: a systematic review and meta-analysis

  • 0Department of General Surgery, Chengdu Second People's Hospital, Chengdu, China; School of Clinical Medicine, Chengdu Medical College, Chengdu, China.
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract +

|

November 28, 2024

|

November 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Postoperative skeletal muscle loss in gastric cancer patients is common and linked to worse survival. Early identification and interventions like nutrition and exercise are crucial for better outcomes.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Metabolism

Background

  • Skeletal muscle mass decrease is common in gastric cancer patients perioperatively.
  • This muscle loss correlates with increased postoperative complications and reduced long-term survival.
  • A significant portion of gastric cancer patients experience post-surgery muscle wasting.

Purpose Of The Study

  • To systematically review and meta-analyze the prognostic value of postoperative skeletal muscle loss in gastric cancer patients.
  • To assess the association between skeletal muscle mass changes and clinical outcomes after gastric cancer surgery.

Main Methods

  • A systematic literature search was conducted across PubMed, Web of Science, and Embase.
  • Inclusion and exclusion criteria were strictly applied to select relevant studies.
  • Meta-analysis examined the impact of postoperative skeletal muscle loss on overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), and disease-specific survival (DSS).

Main Results

  • 10 studies involving over 3764 gastric cancer patients were analyzed.
  • Severe postoperative skeletal muscle loss was observed in 25.7% of patients.
  • Significant muscle loss was associated with poorer OS, RFS, DFS, and DSS. Sarcopenia also correlated with worse OS.

Conclusions

  • Gastric cancer patients undergoing radical surgery frequently experience skeletal muscle mass loss.
  • Significant postoperative muscle loss is a predictor of poorer survival outcomes.
  • Identifying patients with muscle wasting and providing timely nutritional and exercise interventions are vital for improving prognosis.

Keywords: