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Amnesia

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Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
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Transient global amnesia predisposed by rizatriptan and temazepam.

Taylor Sanders¹, Chun Ho Szeto², Divya Parepalli²

¹School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA taylor.sanders@ttuhsc.edu.

BMJ Case Reports

|November 28, 2024

Summary

Transient global amnesia (TGA) can occur after taking migraine and insomnia medications. This case highlights the importance of distinguishing TGA from stroke to avoid unnecessary treatments.

Keywords:

Memory Disorders Neurology (drugs and medicines)Unwanted effects / adverse reactions

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Area of Science:

Neurology
Pharmacology

Background:

Transient global amnesia (TGA) is a neurological disorder characterized by acute anterograde amnesia, typically resolving within 24 hours.
Differential diagnosis of TGA is crucial, requiring exclusion of cerebrovascular events like transient ischemic attack (TIA) and stroke.

Observation:

A woman in her 60s presented with acute memory loss and confusion after using rizatriptan for migraine and temazepam for insomnia.
Initial management considered acute ischemic stroke, with tissue plasminogen activator administered.

Findings:

A comprehensive neurological evaluation led to a diagnosis of TGA after ruling out other causes.
The case suggests a potential link between the combined use of triptans and benzodiazepines and the precipitation of TGA.

Implications:

This case underscores the importance of considering medication interactions, specifically triptans and benzodiazepines, as potential triggers for TGA.
Accurate differentiation of TGA from cerebrovascular diseases is vital to prevent inappropriate thrombolytic therapy and reduce healthcare costs.