Related Experiment Video

Updated: Jun 6, 2025

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

47.8K

Intravoxel incoherent motion imaging in stroke infarct core and penumbra is related to long-term clinical outcome

Josua Zimmermann1,2, Beno Reolon3, Lars Michels3,4,5

  • 1Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, CH-8091, Switzerland. josua.zimmermann@uzh.ch.

Scientific Reports
|November 28, 2024
PubMed

Insights

Intravoxel incoherent motion (IVIM) imaging reveals that reduced microvascular perfusion in the stroke core and penumbra predicts poor recovery. IVIM characteristics are strong prognostic factors for long-term outcomes in acute stroke patients.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Intravoxel incoherent motion (IVIM) imaging is a contrast-free MRI technique for assessing microvascular perfusion abnormalities in acute stroke.
  • Previous studies show reduced IVIM values in the stroke infarct core, but findings in the penumbra are inconsistent.
  • The prognostic value of IVIM characteristics for clinical outcomes in stroke patients is largely unknown.

Purpose of the Study:

  • To investigate the role of IVIM imaging in characterizing microvascular perfusion in acute ischemic stroke.
  • To evaluate the association between IVIM parameters and clinical outcomes 90 days post-stroke.
  • To assess the prognostic value of IVIM in infarct core and penumbra following endovascular treatment.

Main Methods:

  • A longitudinal multimodal imaging approach was used in 24 ischemic stroke patients, including IVIM, diffusion-weighted, and contrast-enhanced perfusion-weighted imaging.
  • IVIM parameters were assessed pre-/post-treatment and at 90-day follow-up.
  • Statistical analysis correlated IVIM perfusion fraction with the NIH Stroke Scale (NIHSS) and other prognostic factors.

Main Results:

  • Reduced post-treatment IVIM perfusion fraction in the infarct core and recanalized penumbra correlated with poorer functional recovery (NIHSS) at 90 days (r=-0.64 and r=-0.69).
  • Incorporating IVIM perfusion fraction significantly increased the explained variance of NIHSS from 42% to 83% compared to age and core volume.
  • IVIM perfusion fraction was lower in the core and recanalized penumbra than in contralateral healthy tissue, indicating impaired microvascular reperfusion.

Conclusions:

  • IVIM imaging characteristics of the infarct core and recanalized penumbra serve as potent prognostic indicators for long-term outcomes in stroke patients.
  • IVIM demonstrates significant potential for characterizing microvascular perfusion abnormalities in stroke, aiding in outcome prediction.
Keywords:
Acute stroke imagingInfarct coreIntravoxel incoherent motion imagingLong-term clinical outcomeMagnetic resonance imagingMicrovascular perfusionPenumbraStroke

More Related Videos

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke06:45

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

1.3K
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

14.0K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
6
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
3
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
197
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
3
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
210
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K