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Association of abnormal P-wave parameters with all-cause mortality in diffuse large B-cell lymphoma
Hanzhi Du1, Qinghua Tang2, Yuye Ning3
1Department of Hematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Scientific Reports
|November 28, 2024
Summary
Abnormal P-wave parameters (PWPs) predict mortality in diffuse large B-cell lymphoma (DLBCL) patients. Monitoring PWPs, especially in males, can improve prognosis assessment for DLBCL.
Area of Science:
- Cardiology
- Hematology
- Oncology
Background:
- Diffuse large B-cell lymphoma (DLBCL) patients have an increased risk of atrial fibrillation (AF).
- Abnormal P-wave parameters (PWPs) are known AF predictors, but their prognostic role in DLBCL is unclear.
Purpose of the Study:
- To investigate the prognostic significance of PWPs in predicting all-cause mortality among newly diagnosed DLBCL patients.
- To identify risk factors associated with abnormal PWPs in this cohort.
Main Methods:
- Retrospective study of 374 DLBCL patients diagnosed between January 2015 and August 2022.
- Analysis of P-wave parameters (PWPs) and their correlation with all-cause mortality using Kaplan-Meier and Cox regression models.
- Logistic regression used to identify risk factors for abnormal PWPs.
Main Results:
- 137 patients (36.6%) had abnormal PWPs.
- Abnormal PWPs were associated with higher all-cause mortality (p=0.001), male sex (p=0.001), elevated blood urea nitrogen (p=0.038), and creatinine (p=0.005).
- P-wave duration and P-wave terminal force in lead V1 (PTFV1) were independent predictors of mortality.
Conclusions:
- PWPs, specifically P-wave duration and PTFV1, are simple and effective prognostic indicators for all-cause mortality in DLBCL patients.
- Vigilant monitoring of PWPs, particularly in male DLBCL patients, is recommended for prognosis evaluation.
