Related Experiment Video
Updated: Jun 6, 2025
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Related factors of bloodstream infections associated with urinary tract infections and pathogenetic characteristics
Yanxia Shao1,2, Wei Jia3,4, Gang Li5,6
1School of Clinical Medicine, Ningxia Medical University, Yinchuan, People's Republic of China.
Objectives:
To explore correlations between biomarker indices and urosepsis severity, and investigate the prevalence of drug-resistant Escherichia coli in a patient population at the General Hospital of Ningxia Medical University in the Ningxia region of China.
Methods:
Patients with urinary tract infection-associated sepsis were categorized into three groups: a septic non-shock group (NSSPU), a septic shock group (USG), and a control group with non-sepsis cases of simple urinary tract infections (CG). The study analyzed various biomarkers, including the percentage of neutrophils (N%), neutrophil-to-lymphocyte ratio (NLR), and lactate (La), to assess their predictive value for urogenital sepsis severity.
Results:
The Kruskal-Wallis test showed significant differences in all measured biomarkers between the groups. ROC curve analysis identified N%, NLR, total protein (TP), albumin (ALB), and La as meaningful predictors of urosepsis severity. The combined detection indicators hold greater value in diagnosing uroseptic shock compared to individual test indicators. In addition, the study confirmed the prevalence of drug-resistant E. coli in cases of septic shock.
Conclusion:
The combined monitoring of N%, NLR, La, TP, and ALB proves beneficial in the clinical diagnosis of uroseptic shock. This study emphasizes the significance of monitoring Escherichia coli and its resistance patterns to decrease the occurrence of sepsis complications.
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