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Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...

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Related Experiment Video

Updated: Jun 6, 2025

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

Malignant hyperthermia during orthognathic surgery: a case report.

Yue Li¹, Jie Lin¹, Wei Luo¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Anesthesia, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology

|November 29, 2024

Summary

Malignant hyperthermia, a rare anesthesia complication, was successfully treated with dantrolene. Prompt recognition and treatment with dantrolene are crucial for managing this life-threatening condition.

Keywords:

anesthesia creatine kinase dantrolene malignant hyperthermia myoglobin orthog-nathic surgery sevoflurane

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Area of Science:

Anesthesiology
Pharmacology
Genetics

Background:

Malignant hyperthermia is a rare, life-threatening hyperthermic reaction during general anesthesia.
Preoperative diagnosis of malignant hyperthermia is challenging.
Genetic testing often confirms malignant hyperthermia post-episode.

Purpose of the Study:

To report a case of malignant hyperthermia during orthognathic surgery.
To highlight the efficacy of dantrolene in treating malignant hyperthermia.

Main Methods:

Case report of malignant hyperthermia during orthognathic surgery.
Administration of dantrolene for treatment.
Postoperative monitoring of myoglobin and creatine kinase levels.

Main Results:

Malignant hyperthermia was successfully reversed with prompt dantrolene treatment.
Only slight postoperative increases in myoglobin and creatine kinase were observed.

Conclusions:

Dantrolene is the specific and effective treatment for malignant hyperthermia.
Prompt recognition and treatment are vital for improved outcomes in malignant hyperthermia cases.