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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

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The impact of diabetes on tight junctions in cardiomyopathy dysfunction

Leila Chodari1,2, Sina Fatehfar3, Mahan Ahmadi4

  • 1Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.

Journal of Diabetes and Metabolic Disorders
|November 29, 2024
PubMed

Insights

Diabetic cardiomyopathy impairs heart function through ventricular dysfunction. This review explores how diabetes affects cellular tight junctions and Zona occludens (ZO) proteins, contributing to cardiovascular issues.

Area of Science:

  • Cardiology
  • Endocrinology
  • Cell Biology

Background:

  • Diabetic cardiomyopathy presents as ventricular dysfunction in diabetes, unrelated to other heart diseases.
  • Associated factors include left ventricular hypertrophy, metabolic disruption, and oxidative stress.
  • Tight junctions, crucial for cell barriers, are implicated in diabetic vascular complications.

Purpose of the Study:

  • To review the impact of diabetes on cellular tight junctions.
  • To examine the role of Zona occludens (ZO) proteins in diabetic cardiovascular dysfunction.

Main Methods:

  • Literature review focusing on cellular and molecular mechanisms.
  • Analysis of studies investigating tight junction proteins (claudins, occludens, ZO proteins) in diabetes.

Main Results:

  • Diabetes alters the structure and function of tight junctions.
  • Expression and localization of Zona occludens (ZO) proteins are affected by diabetic conditions.
  • These changes contribute to the development of diabetic cardiomyopathy.

Conclusions:

  • Tight junction integrity, particularly involving ZO proteins, is compromised in diabetes.
  • Restoring tight junction function may offer a therapeutic target for diabetic cardiomyopathy.

Keywords:
Diabetic cardiomyopathyTight junctionZona occludens

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