Role of different examination methods in colorectal cancer screening: Insights and future directions

Colorectal cancer is a malignant tumor with the third and second highest incidence and mortality rates worldwide, and its mortality rate is increasing annually. Colorectal cancer evolves gradually over a long period of time. The evolving process from colorectal adenoma to colorectal cancer takes approximately 10-15 years, providing a sufficiently long "window period" for early screening and diagnosis of colorectal cancer. The recurrence and mortality rates can be controlled at a low level with an early intervention. Metaxas et al sum-marized existing screening methods and their applicable scope in a recent publication. Moreover, they provide suggestions on how to improve adherence. This editorial provides a commentary on their article and discuss the roles of different screening methods in the early screening of colorectal cancer.