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Microboost in Localized Prostate Cancer: Analysis of a Statewide Quality Consortium.

Samuel N Regan1, Michael Dykstra1, Huiying Yin1

  • 1Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

Advances in Radiation Oncology
|November 29, 2024
PubMed
Summary
This summary is machine-generated.

External beam radiation therapy (EBRT) microboost for prostate cancer is underutilized, with only 10% of patients receiving it. Significant variations in adoption exist across treatment facilities, highlighting a need for further investigation into utilization barriers.

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Area of Science:

  • Radiation Oncology
  • Urologic Oncology
  • Medical Physics

Background:

  • External beam radiation therapy (EBRT) microboost shows promise for improved oncologic outcomes and isotoxicity in localized prostate cancer.
  • Current adoption rates and practice patterns of EBRT microboost are not well-established.

Purpose of the Study:

  • To investigate the current utilization of EBRT microboost for localized prostate cancer within a multicenter quality consortium.
  • To identify factors associated with microboost receipt and evaluate facility-level variations in its application.

Main Methods:

  • Analysis of prospectively collected data from 26 centers between October 2020 and June 2023.
  • Inclusion of men with intermediate- and high-risk prostate adenocarcinoma treated with curative-intent radiation.
  • Multivariable and mixed-effects modeling to assess associations with microboost use and facility-level variability.

Main Results:

  • EBRT microboost was used in 10% of eligible patients across 27% of participating sites.
  • Factors associated with microboost use included Grade group 4/5, MRI-based planning, and fiducial marker/rectal spacer placement.
  • Significant facility-level variability in microboost use was observed (0% to 71%).

Conclusions:

  • Despite evidence of benefit, EBRT microboost adoption remains low with substantial heterogeneity across facilities.
  • Further research is needed to understand and overcome barriers to microboost utilization in clinical practice.