Aberrant Dynamic Network Connectivity Changes in Comorbid Depression and Overweight/Obesity: Insights From the Triple
Zhu-Qing Zhang1, Dan Liao2, Zhi-Peng Guo3
1Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Journal of Neuroscience Research
|November 29, 2024
Summary
Major depressive disorder (MDD) with overweight/obesity shows altered brain network dynamics, specifically reduced flexibility and enhanced default mode network (DMN) and executive control network (ECN) connectivity, impacting depressive symptom severity.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Major depressive disorder (MDD) and overweight/obesity frequently co-occur, presenting complex biopsychological challenges.
- Neural mechanisms, particularly functional network connectivity (FNC), underlying this comorbidity remain poorly understood.
Purpose of the Study:
- To investigate the neural mechanisms of comorbid MDD and overweight/obesity using resting-state functional magnetic resonance imaging (rs-fMRI).
- To differentiate between static and dynamic functional network connectivity (FNC) in individuals with MDD and overweight/obesity.
Main Methods:
- Analysis of rs-fMRI data from 57 MDD with overweight/obesity (MDD-OW), 57 MDD normal weight (MDD-NW), and 44 healthy controls.
- Utilized independent component analysis, sliding window analysis, K-means clustering, and graph theory to assess static and dynamic FNC.
- Examined functional coordination and nodal characteristics across identified brain states.
Main Results:
- Static FNC showed no significant differences between groups.
- Dynamic FNC analysis revealed four consistent states, with both MDD groups exhibiting reduced flexibility and salience network alterations.
- The MDD-OW group showed increased dynamic FNC between the default mode network (DMN) and executive control network (ECN), inversely correlated with depressive symptom severity.
Conclusions:
- Dynamic FNC, not static FNC, is crucial for understanding MDD with overweight/obesity.
- Altered DMN-ECN dynamic connectivity may serve as a biomarker for depressive states in comorbid conditions.
- Findings offer insights into brain network dynamics in MDD-OW and inform therapeutic strategies.
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