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Hyperomocysteinemia in an Unselected Female Population: Incidence and Treatment Options

Francesca Manganello1, Giuseppe Mungo1, Donatella Rettore1

  • 1Polimedica s.r.l. - Trebaseleghe (PD), Mirano (Venice), Italy.

Journal of Medicinal Food
|November 29, 2024
PubMed

Insights

Hyperhomocysteinemia, high homocysteine (HCys) levels, is prevalent in women. A specialized food product, EUCIS PLUS, effectively reduced HCys levels by 36% in a two-month trial.

Area of Science:

  • Clinical Medicine
  • Nutritional Science
  • Biochemistry

Background:

  • Homocysteine (HCys) is a key amino acid metabolite.
  • Elevated HCys (hyperhomocysteinemia) is linked to cardiovascular and neurological risks.
  • Hyperhomocysteinemia is often underdiagnosed.

Purpose of the Study:

  • To determine the incidence of hyperhomocysteinemia in an unselected female population.
  • To evaluate the efficacy of EUCIS PLUS, a Food for Special Medical Purposes (FSMP), in lowering HCys levels.

Main Methods:

  • Two-phase study involving 181 women (Phase 1) and 44 women with elevated HCys (Phase 2).
  • Incidence and mean HCys levels were measured in Phase 1.
  • EUCIS PLUS was administered for two months to participants with HCys >10 µmol/L in Phase 2.

Main Results:

  • Phase 1 revealed an 81.2% incidence of hyperhomocysteinemia with a mean HCys level of 15.4 µmol/L.
  • Phase 2 showed a 36% average reduction in HCys levels after two months of EUCIS PLUS treatment, reaching 10.7 µmol/L.
  • EUCIS PLUS was well-tolerated.

Conclusions:

  • Hyperhomocysteinemia is a common and underdiagnosed condition in women.
  • EUCIS PLUS demonstrates significant potential as an effective and well-tolerated therapeutic option for managing hyperhomocysteinemia.

Keywords:
EUCIS PLUSatherosclerosisfood for special medical purposeshomocysteinehyperhomocysteinemiametabolismneurology

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