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Related Experiment Videos

Multiple system atrophy (Shy-Drager syndrome): MR imaging.

B Pastakia, R Polinsky, G Di Chiro

    Radiology
    |May 1, 1986
    PubMed
    Summary

    Shy-Drager syndrome (SDS), a progressive autonomic failure, shows distinct basal ganglia changes on MRI. This imaging can help differentiate SDS from Parkinson disease by revealing putaminal atrophy and signal abnormalities.

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    Area of Science:

    • Neurology
    • Radiology
    • Medical Imaging

    Background:

    • Shy-Drager syndrome (SDS) is a progressive autonomic nervous system failure (PAF) often misdiagnosed as Parkinson disease.
    • SDS involves orthostatic hypotension and extrapyramidal symptoms, with associated olivopontocerebellar atrophy and striatonigral degeneration.

    Purpose of the Study:

    • To investigate the utility of Magnetic Resonance (MR) imaging in detecting in vivo basal ganglia abnormalities in patients with Shy-Drager syndrome.
    • To compare imaging findings between 0.5-T and 1.5-T MR systems.

    Main Methods:

    • Eight patients with SDS underwent MR imaging using T1-weighted inversion recovery (IR) and T2-weighted spin-echo sequences on a 0.5-T system.
    • The same patients were also imaged on a 1.5-T system using spin-echo sequences.

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    Main Results:

    • MR imaging, particularly with IR sequences, revealed atrophy of the putamina in SDS patients, consistent with postmortem findings.
    • Decreased signal intensity in the putamina was observed, predominantly on T2-weighted sequences, and in some cases on T1-weighted spin-echo sequences.
    • Abnormalities were more clearly visualized on the 1.5-T system.

    Conclusions:

    • MR imaging can demonstrate in vivo basal ganglia changes in Shy-Drager syndrome, specifically putaminal atrophy and signal alterations.
    • These findings aid in the in vivo diagnosis of SDS and its differentiation from Parkinson disease.
    • This study highlights MR imaging as a key tool for identifying specific basal ganglia changes in SDS.