Related Experiment Video
Updated: Jun 6, 2025
Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition
Published on: August 18, 2023
Evaluation of optic nerve sheath diameter measurements in postictal pediatric patients
İpek Dokurel Çetin1, Nihan Şık2
1Department of Pediatrics, Division of Pediatric Neurology, Balıkesir University Medical Faculty, 10100, Balıkesir, Turkey. dripekdokurel@gmail.com.
Insights
Optic nerve sheath diameter (ONSD) is elevated in postictal children, correlating with seizure duration. While ONSD shows promise, it requires further study for accurate assessment of prolonged seizures in children.
Area of Science:
- Pediatric Neurology
- Neuroimaging
- Ophthalmology
Background:
- Prolonged seizures can lead to cytotoxic edema and increased intracranial pressure.
- Optic nerve sheath diameter (ONSD) and its ratio to eyeball transverse diameter (ONSD/ETD) provide a noninvasive method for monitoring intracranial pressure.
- This study investigates the utility of ONSD and ONSD/ETD in postictal children.
Purpose of the Study:
- To calculate ONSD and ONSD/ETD in postictal children using computed tomography.
- To evaluate the relationship between ONSD/ETD values and seizure duration.
- To assess the diagnostic accuracy of ONSD for identifying prolonged seizures.
Main Methods:
- Non-contrast computed head tomography was used to measure ONSD and ONSD/ETD in 88 postictal children and 109 healthy controls.
- ONSD was measured 3 mm from the optic disc, and ETD was the widest corneal diameter.
- Statistical analyses were performed to compare groups and assess correlations.
Main Results:
- Postictal children had significantly higher median ONSD and ONSD/ETD compared to controls (p < 0.001).
- Children with prolonged seizures showed significantly different ONSD values (p=0.015) and a correlation between ONSD and seizure duration (r=0.257, p=0.016).
- An ONSD cutoff of >4.84 mm demonstrated 65.6% sensitivity and 72.5% specificity for prolonged seizures.
Conclusions:
- ONSD and ONSD/ETD are potentially useful for evaluating postictal children.
- These parameters alone lack sufficient discriminative accuracy for prolonged seizures.
- Further research is needed to explore the significance of ONSD in monitoring seizure duration in pediatric populations.
Introduction:
Prolonged seizures cause cytotoxic edema and increase intracranial pressure. Optic nerve sheath diameter (ONSD) and its ratio to eyeball transverse diameter (ONSD/ETD) offer a noninvasive method for monitoring intracranial pressure changes. We calculated the ONSD and ONSD/ETD ratio of postictal children using computed tomography and evaluated the relationship between those values and seizure duration.
Methods:
The ONSD and ONSD/ETD ratios were calculated using non-contrast computed head tomography for 88 postictal children with generalized and focal seizures and 109 healthy controls. ONSD was measured as the thickness at 3 mm from the optic disc and the ETD was measured as the widest diameter of the eyeball from retina to retina. The ONSD/ETD ratio was obtained by averaging the left and right ONSD values and dividing that value by the mean of the left and right ETD values.
Results:
Fifty-eight (63.6%) of the children had focal seizures, and 64% of the seizures of 59 children (67%) were classified as prolonged seizures. The median ONSD and ONSD/ETD ratio were significantly higher in postictal children compared to healthy controls (p < 0.001 and p < 0.001, respectively). In postictal children presenting with generalized seizures, nonsignificant differences in the median ONSD and ONSD/ETD ratio were observed (p = 0.43 and p < 0.87, respectively). Children with prolonged seizures had significantly different ONSD values (p = 0.015) but the ONSD/ETD ratio did not differ significantly (p = 0.87). The analysis of postictal children indicated a significant correlation between seizure duration and ONSD (r = 0.257, p = 0.016), but not the ONSD/ETD ratio (r = 0.065, p = 0.545). ONSD values of (> 4.84 mm) were most effective in distinguishing patients with prolonged seizures compared to those without, with sensitivity and specificity of 65.6% and 72.5%.
Conclusion:
ONSD and ONSD/ETD values are potentially useful in the evaluation of postictal children, but they do not exhibit adequate discriminative accuracy by themselves. The significance of these parameters in observing seizure duration in postictal children may be a critical area of interest for future investigations.
