The conversion of electroanatomic maps for compatibility with treatment planning systems in cardiac radioablation...

Cardiac radioablation (CRA) is a new and promising treatment modality for patients with ventricular tachycardia refractory to standard-of-care treatment. Electroanatomic maps are used to define radiation target volumes; however, there is currently no native method to import electroanatomic maps into the treatment planning system (TPS).

To develop Edico, a semi-automated tool to enable electroanatomic map import into a TPS, by converting electroanatomic maps to a Digital Imaging and COmmunications in Medicine (DICOM) standard. The overall aim is to facilitate target volume delineation and improve workflow efficiency in treating patients.

Edico imports voltage and spatial data from electroanatomic maps and sorts these into voxels to be exported in a DICOM format, with each voxel containing the average voltage value of the data that falls within it. Three different rectangular electroanatomic maps were created and processed using Edico to ensure that expected features are maintained through processing. A sensitivity analysis of voxel size was completed using 19 different electroanatomic maps processed at five different sets of voxel dimensions, for a total of 95 resulting voxelized datasets. The coefficient of variation in each populated voxel in the datasets was analyzed to determine which voxel sizes are necessary to ensure that data loss is kept to a minimum throughout processing, despite averaging. Five electroanatomic maps were used to re-contour clinical target volumes and planning target volumes for previously-treated patients with their electroanatomic maps now directly registered to their planning computed tomography (CT) scans.

All three rectangular test electroanatomic maps were processed as expected. All tested voxel sizes resulted in low coefficients of variation overall, with the exception of the largest voxel size of 1.8 × 1.8 × 8 mm. When using Edico, a user should choose voxel dimensions similar to or smaller than those of a planning CT. Of five pairs of clinical and planning target volumes from previously treated patients, adjustments were made to four (80%), retrospectively, using the electroanatomic maps generated using Edico, registered to the patients' planning CTs.

Edico provides a reliable solution for electroanatomic map import into a TPS and facilitates clinical and planning target volume identification in CRA.