Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.

Nature communications·2026
Same author

IDEA-FAST clinical study protocol: Identifying digital end-points of fatigue, sleep quality and daytime sleepiness in N = 2000.

Digital health·2026
Same author

AI implementation in pediatric radiology for patient safety: a multisociety statement from the ACR, ESPR, SPR, SLARP, AOSPR, SPIN: Reply to Shelmerdine et al.

Pediatric radiology·2026
Same author

Tissue morphology predicts telomere shortening in human tissues.

Cell reports methods·2026
Same author

'Challenges and opportunities for imaging on a global scale' special collection-introductory editorial.

BJR open·2026
Same author

PEERing into the Future: Benchmarking the ANSTO Australian Synchrotron's Very-High-Energy Electron Linac for Ultra-High Dose-Rate, In Vivo FLASH Radiotherapy Research.

Cancers·2026

Related Experiment Video

Updated: Jun 6, 2025

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

11.8K

First linac-mounted photon counting detector for image guided radiotherapy: Planar image quality characterization.

Sean Hood1, Matthew Newall2, Phil Butler3

  • 1Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.

Medical Physics
|November 29, 2024
PubMed
Summary

Photon-counting detectors (PCDs) show improved image quality for image-guided radiotherapy (IGRT). This study demonstrates enhanced spatial resolution and contrast with linac-mounted PCDs compared to traditional flat-panel detectors (FPDs).

Keywords:
IGRTphoton counting detectorsspectral CBCT

More Related Videos

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

14.4K
Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera
06:28

Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera

Published on: January 30, 2020

12.5K

Related Experiment Videos

Last Updated: Jun 6, 2025

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

11.8K
X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

14.4K
Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera
06:28

Visualization of Low-Level Gamma Radiation Sources Using a Low-Cost, High-Sensitivity, Omnidirectional Compton Camera

Published on: January 30, 2020

12.5K

Area of Science:

  • Medical Physics
  • Radiotherapy Imaging
  • Detector Technology

Background:

  • Image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) is limited by suboptimal soft-tissue contrast and spatial resolution of energy-integrating flat-panel detectors (FPDs).
  • Spectral computed tomography (CT) with high-resolution photon-counting detectors (PCDs) offers potential improvements in tumor delineation through enhanced soft-tissue contrast, spatial resolution, dose efficiency, and CT number accuracy.

Purpose of the Study:

  • To present the first linac-mounted photon-counting detector (PCD) for spectral cone-beam CT (CBCT) in image-guided radiotherapy (IGRT).
  • To fundamentally characterize and compare the planar image quality of a linac-mounted PCD against a conventional flat-panel detector (FPD) regarding 2D spatial resolution, noise, and contrast.

Main Methods:

  • A Medipix3RX-based PCD was integrated into an Elekta linac's kilovoltage (kV) X-ray volume imaging (XVI) system, synchronized with the pulsed kV source.
  • 2D spatial resolution and noise were assessed using pre-sampling modulation transfer function (MTF) and normalized noise power spectrum (NPS) with an RQA5 spectrum and a fluoroscopy phantom.
  • Spectral planar images of phantom inserts (calcium and iodine) were acquired at various kVp settings (60-120 kV) and optimally energy-weighted to maximize contrast, with dynamic flat-field corrections applied.

Main Results:

  • The Medipix3RX PCD demonstrated linear energy calibration up to 60 keV.
  • Limiting resolution improved from 2 lp/mm (FPD) to 5 lp/mm (PCD), with higher pre-sampling MTF across all frequencies for the PCD.
  • Energy-weighted contrast for a 60 mg/cc calcium insert increased significantly with the PCD compared to the FPD at both 60 kV and 120 kV.

Conclusions:

  • Successful integration of a Medipix3RX-based PCD with a linac-mounted kilovoltage imaging system was achieved.
  • Initial characterization revealed superior planar image quality, including improved MTF and energy-weighted contrast, compared to FPDs.
  • Addressing sensor response variations during acquisition is crucial for realizing the full potential of linac-mounted spectral CBCT.