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Functional evaluation in stage I pulmonary sarcoidosis.
Respiration; International Review of Thoracic Diseases
|January 1, 1986
Summary
Early-stage sarcoidosis (Stage I) can show small airway issues. Functional evaluation revealed impaired lung compliance and conductance, suggesting granulomatous infiltration around small airways.
Area of Science:
- Pulmonary Medicine
- Respiratory Physiology
Background:
- Sarcoidosis is an inflammatory disease that can affect the lungs.
- Hilar adenopathy on chest roentgenograms indicates Stage I sarcoidosis.
Purpose of the Study:
- To evaluate lung function in patients with Stage I sarcoidosis.
- To identify early signs of small airway impairment in sarcoidosis.
Main Methods:
- Functional evaluation of 9 non-smoking patients with Stage I sarcoidosis.
- Assessment of frequency dependence of compliance and upstream segment conductance.
Main Results:
- Five patients exhibited frequency dependence of compliance.
- Three patients showed decreased conductance of the upstream segment.
- These findings indicate small airway dysfunction.
Conclusions:
- Small airway impairment can be detected even in early-stage sarcoidosis (Stage I).
- Findings suggest peribronchiolar granulomatous infiltration as a potential cause.