Related Experiment Video

Updated: Aug 12, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

A predictive approach to selecting the size of a clinical trial, based on subjective clinical opinion

D J Spiegelhalter, L S Freedman

    Statistics in Medicine
    |January 1, 1986
    PubMed

    More Related Videos

    A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

    A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

    Published on: January 11, 2020

    Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index06:55

    Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

    Published on: January 8, 2020

    Related Concept Videos

    Clinical Trials01:16

    Clinical Trials

    Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
    There are four phases in a clinical trial. A phase one...
    Clinical Trials: Overview01:11

    Clinical Trials: Overview

    Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
    Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

    Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

    Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
    Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
    Dosage Regimens: Designs and Approaches01:28

    Dosage Regimens: Designs and Approaches

    Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
    Dosage Regimen: Individualization01:24

    Dosage Regimen: Individualization

    Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
    Dose Size and Dosing Frequency: Determination Methods01:21

    Dose Size and Dosing Frequency: Determination Methods

    Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...