Related Experiment Video

Updated: Jun 6, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.1K

RNA binding proteins: Mechanistic considerations and perspectives in controlling cardiovascular diseases

Lanlan Li1, Saiyang Xie1, Wei Deng1

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, China; Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China.

European Journal of Pharmacology
|November 29, 2024
PubMed

Insights

RNA-binding proteins (RBPs) are key regulators in cardiovascular diseases (CVDs). Targeting RBPs offers promising therapeutic strategies for conditions like myocardial hypertrophy and dilated cardiomyopathy.

Area of Science:

  • Molecular Biology
  • Cardiology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) present a significant global health challenge due to rising morbidity and mortality.
  • Numerous molecular targets are implicated in the complex pathology of CVDs.
  • RNA-binding proteins (RBPs) are emerging as crucial regulators in RNA metabolism and gene expression.

Purpose of the Study:

  • To review the regulatory roles of RBPs in various cardiovascular diseases at the post-transcriptional level.
  • To explore the potential of RNA-based therapeutics for treating CVDs.

Main Methods:

  • Literature review of current research on RBPs and cardiovascular diseases.
  • Analysis of the involvement of RBPs in myocardial hypertrophy, dilated cardiomyopathy (DCM), myocardial fibrosis, and pulmonary hypertension (PH).

Main Results:

  • RBPs play critical roles in regulating RNA metabolism and gene expression.
  • Dysregulation of RBPs is associated with the development and progression of various CVDs.
  • RBPs influence key pathological processes including myocardial hypertrophy, DCM, fibrosis, and PH.

Conclusions:

  • RBPs represent promising molecular targets for the prevention and treatment of cardiovascular diseases.
  • RNA-based therapeutic strategies targeting RBPs hold potential for future CVD management.

Keywords:
Cardiovascular diseaseRNA therapeuticsRNA-Binding proteins

More Related Videos

Dynamic Continuous Blood Extraction from Rat Heart via Noninvasive Microdialysis Technique04:52

Dynamic Continuous Blood Extraction from Rat Heart via Noninvasive Microdialysis Technique

Published on: September 13, 2022

2.2K
Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.6K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
59
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.4K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

2.0K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
436