Related Experiment Video

Updated: Jun 6, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
10:44

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures

Published on: March 28, 2017

9.8K

Consensus on the key characteristics of metabolism disruptors

Michele A La Merrill1, Martyn T Smith2, Cliona M McHale2

  • 1Department of Environmental Toxicology, University of California, Davis, CA, USA. mlamerrill@ucdavis.edu.

Nature Reviews. Endocrinology
|November 29, 2024
PubMed

Insights

Metabolism-disrupting agents (MDAs) increase metabolic disorder risk. This study defines 12 key characteristics (KCs) to systematically identify MDAs from chemical, infectious, or physical sources.

Area of Science:

  • Toxicology
  • Endocrinology
  • Metabolic Health

Background:

  • Metabolism-disrupting agents (MDAs) pose risks for metabolic disorders.
  • Existing studies on MDAs lack a systematic integration method for hazard identification.
  • Pharmaceuticals and environmental agents are examples of MDAs.

Purpose of the Study:

  • To develop a systematic method for identifying metabolism-disrupting agents (MDAs).
  • To define key characteristics (KCs) for recognizing MDAs, inspired by carcinogen identification.
  • To organize and utilize mechanistic data for MDA hazard identification.

Main Methods:

  • Developed 12 key characteristics (KCs) for MDAs based on underlying disease processes and agent effects.
  • KCs cover endocrine pancreas, adipose tissue, nervous system, insulin resistance, signaling pathways, cell development, energy homeostasis, nutrient handling, inflammation, gastrointestinal function, cellular stress, and circadian rhythms.
  • Applied logic to reveal KCs and gathered supporting evidence.

Main Results:

  • Established 12 KCs for MDAs.
  • Demonstrated how KCs can organize mechanistic data for hazard identification.
  • Illustrated the use of KCs with examples of chemical, infectious, and physical agents.

Conclusions:

  • The 12 KCs provide a framework for systematic MDA identification.
  • This approach aids in integrating diverse evidence to identify metabolic disorder hazards.
  • The KCs facilitate a structured understanding of how agents disrupt metabolic function.

More Related Videos

Elucidating the Metabolism of 2,4-Dibromophenol in Plants06:54

Elucidating the Metabolism of 2,4-Dibromophenol in Plants

Published on: February 10, 2023

789
Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants08:22

Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants

Published on: December 22, 2023

498

Related Concept Videos

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in...
187
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
1
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
112
What is Metabolism?00:52

What is Metabolism?

Overview
113.3K
Drug Biotransformation: Overview01:28

Drug Biotransformation: Overview

Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
376
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
29.5K