Selective binding and removal of copper from biological fluids-why are PSP ligands so efficient?
Peter Faller1,2
1Institut de Chimie-UMR7177, Université de Strasbourg, Centre National de la Recherche Scientifique, 4 rue B. Pascal, Strasbourg, France. pfaller@unistra.fr.
Abstract:
The following comment tries to answer why the reported removal of copper from buffer, cell culture medium, and cell extract by a supported chelator called phenPS is so selective and efficient. It is further argued that the family of PSP (phosphine sulfide-stabilized phosphines) chelators, due to their unique properties, have various potential future application in biology and medicine such as chelation therapy, copper-sensors, or tools to understand copper metabolism.
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