Effect of Zinc on Blood Biochemical and mTOR Gene Expression in Rats with Polycystic Ovarian
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Zinc supplementation, particularly organic forms, can mitigate polycystic ovarian syndrome (PCOS) by reducing insulin resistance (IR) and normalizing mTOR signaling pathways. This study shows Zn
Area Of Science
- Reproductive Endocrinology
- Nutritional Biochemistry
- Molecular Metabolism
Background
- Polycystic ovarian syndrome (PCOS) is frequently associated with insulin resistance (IR).
- Mammalian target of rapamycin (mTOR) signaling, crucial for cellular functions, is implicated in PCOS pathogenesis and regulated by insulin and nutrients.
- mTOR forms complexes mTORC1 and mTORC2 with Raptor and Rictor, respectively, and is activated in PCOS.
Purpose Of The Study
- To investigate the impact of zinc (Zn) supplementation on mTOR signaling gene expression (Raptor and Rictor) and insulin resistance (IR) in a rat model of PCOS.
- To evaluate the efficacy of different concentrations of organic zinc (Zn methionine) in ameliorating PCOS-related metabolic disturbances.
Main Methods
- Estradiol Valerate (EV) was used to induce PCOS in rats.
- Rats were supplemented with varying doses of zinc methionine (ZnMet): 25, 75, and 175 mg/kg for six weeks.
- Measurements included fasting glucose (FG), fasting insulin (FI), IR indices, and the expression levels of Raptor and Rictor genes.
Main Results
- PCOS induction significantly elevated FG, FI, IR indices, and mTOR-related gene expression (Raptor and Rictor).
- Zinc supplementation, especially at 75 mg/kg, effectively reduced these PCOS-induced increases.
- Organic zinc demonstrated a positive effect in reducing IR and suppressing Raptor and Rictor expression in EV-induced PCOS rats.
Conclusions
- Zinc supplementation shows promise as a therapeutic strategy for PCOS.
- A significant correlation between zinc levels and insulin resistance was observed.
- Organic zinc positively modulates key molecular pathways (mTOR signaling) and metabolic parameters in PCOS.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...