Associations between maternal periconceptional exposure to PM2.5 and the risk of cryptorchidism: a case-control study of 4274
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Prenatal exposure to fine particulate matter (PM2.5) during early pregnancy is linked to an increased risk of cryptorchidism in male infants. This study highlights a potential environmental factor affecting male reproductive development.
Area Of Science
- Environmental Health
- Reproductive Epidemiology
- Pediatric Urology
Background
- Cryptorchidism is a common congenital condition in male infants with multifactorial causes.
- Limited evidence exists on the impact of prenatal exposure to fine particulate matter (PM2.5) on cryptorchidism risk.
Purpose Of The Study
- To investigate the association between prenatal exposure to PM2.5 and the incidence of cryptorchidism.
- To evaluate the correlation between maternal exposure to PM2.5 during early pregnancy and the likelihood of cryptorchidism in offspring.
Main Methods
- A 1:1 case-control study design was employed.
- Cases were children diagnosed with cryptorchidism; controls were healthy children without birth defects.
- Prenatal PM2.5 exposure levels were estimated based on residential addresses and historical environmental data.
Main Results
- A positive association was found between PM2.5 exposure in the first two months of pregnancy and cryptorchidism.
- Multivariate logistic regression and sensitivity analyses confirmed the association's stability.
Conclusions
- Maternal exposure to fine particulate matter (PM2.5) during early pregnancy is associated with an increased risk of cryptorchidism.
- Environmental factors like PM2.5 may play a significant role in male reproductive development abnormalities.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...