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Expression of periostin in the epithelium of cholesteatoma with different degrees of ossicular chain destruction and its clinical value in predicting postoperative hearing recovery

  • 0Department of Otorhinolaryngology-Head and Neck Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No. 7 Wei Wu Road, Zhengzhou City, 450000, Henan Province, China.
Biomedical Engineering Online +

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November 29, 2024

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November 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated levels of periostin, Interleukin 6, and tumor necrosis factor-alpha in middle ear cholesteatoma correlate with ossicular chain destruction and predict hearing recovery. These inflammatory markers are key indicators for assessing treatment outcomes.

Area Of Science

  • Otorhinolaryngology
  • Biomarkers in Medicine
  • Surgical Pathology

Background

  • Middle ear cholesteatoma is a destructive epithelial growth.
  • Understanding the molecular mechanisms driving cholesteatoma progression and its impact on hearing is crucial.
  • Periostin, Interleukin 6, and tumor necrosis factor-alpha are implicated in inflammatory and tissue remodeling processes.

Purpose Of The Study

  • To investigate the expression of periostin in middle ear cholesteatoma.
  • To correlate periostin expression with the degree of ossicular chain destruction.
  • To evaluate the potential of periostin, Interleukin 6, and tumor necrosis factor-alpha in predicting postoperative hearing recovery.

Main Methods

  • Retrospective analysis of 100 middle ear cholesteatoma patients and 100 controls.
  • Classification of cholesteatoma patients based on ossicular chain destruction (Maresh grading).
  • Quantification of periostin, Interleukin 6, and tumor necrosis factor-alpha expression; correlation and ROC curve analysis.

Main Results

  • Cholesteatoma patients exhibited significantly higher levels of periostin, IL-6, and TNF-α compared to controls.
  • Expression of these markers increased with the severity of ossicular chain destruction.
  • Higher marker levels were observed in patients with ineffective treatment outcomes.
  • Periostin showed a strong positive correlation with IL-6 and TNF-α.
  • Combined analysis of the three markers yielded a high area under the ROC curve (0.892) for predicting treatment effect.

Conclusions

  • Periostin, IL-6, and TNF-α are significantly upregulated in middle ear cholesteatoma.
  • Their expression levels correlate with ossicular chain destruction severity.
  • These markers serve as valuable indicators for predicting postoperative hearing outcomes in cholesteatoma patients.

Keywords: