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Ferroptosis and the tumor microenvironment.

Kaisa Cui^1,2, Kang Wang³, Zhaohui Huang^4,5

¹Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Huihe Road 200, Wuxi, Jiangsu, 214062, China.

Journal of Experimental & Clinical Cancer Research : CR

|November 29, 2024

Summary

Ferroptosis, an iron-dependent cell death, is crucial in cancer. Non-cancer cells in the tumor microenvironment (TME) regulate cancer progression and therapy resistance via ferroptosis-related crosstalk.

Keywords:

CD8+ T cell Cancer-associated fibroblast Ferroptosis Immunotherapy Tumor microenvironment Tumor-associated macrophage

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Area of Science:

Oncology
Cell Biology
Cancer Research

Background:

Ferroptosis is a regulated cell death pathway defined by iron dependence and oxidative damage.
It plays significant roles in cancer initiation, spread, and treatment response.
The tumor microenvironment (TME) comprises various cellular and non-cellular components influencing cancer.

Purpose of the Study:

To systematically review the role of ferroptosis within the TME.
To explore how ferroptosis influences TME reprogramming, impacting cancer progression and therapeutic resistance.
To summarize ferroptosis-targeted therapeutic strategies for the TME.

Main Methods:

Literature review and synthesis of current research findings.
Analysis of the interplay between ferroptosis and TME components.
Identification of therapeutic strategies targeting ferroptosis in the TME.

Main Results:

Non-cancer cells within the TME, including immune and stromal cells, significantly impact tumor progression and resistance.
Crosstalk between cancer cells and non-cancer cells in the TME is partially mediated by ferroptosis.
Ferroptosis-mediated TME reprogramming affects cancer progression and therapeutic outcomes.

Conclusions:

Ferroptosis is a key regulator of the TME, influencing cancer progression and treatment efficacy.
Targeting ferroptosis within the TME offers promising therapeutic avenues for cancer treatment.
Understanding ferroptosis-TME interactions is critical for developing novel cancer therapies.