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Effect of blood oxidative stress indicators on oral mucositis in patients undergoing radiotherapy for nasopharyngeal carcinoma

  • 0Department of Stomatology, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Haikou, 570102, Hainan, China.
European Journal of Medical Research +

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November 29, 2024

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November 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Oxidative stress markers, including total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-PX), change dynamically during nasopharyngeal carcinoma (NPC) radiotherapy. Persistent elevation of these markers, especially advanced oxidized protein product (AOPP), correlates with severe oral mucositis (SOM) progression.

Area Of Science

  • Biochemistry
  • Oncology
  • Radiotherapy

Background

  • Nasopharyngeal carcinoma (NPC) patients undergoing intensity-modulated radiation therapy (IMRT) often develop oral mucositis (OM).
  • The role of oxidative stress markers in OM progression during NPC radiotherapy requires further investigation.

Purpose Of The Study

  • To investigate the correlation between total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), and advanced oxidized protein product (AOPP) levels and the progression of oral mucositis (OM) in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy.

Main Methods

  • A prospective study of 102 NPC patients undergoing IMRT.
  • Serum T-AOC, GSH-PX, and AOPP levels were measured at baseline (T0) and weeks 2 (T1), 4 (T2), and 6 (T3) of IMRT.
  • Patients were classified into severe OM (SOM) and Non-SOM groups at week 6; logistic regression identified risk factors for SOM.

Main Results

  • At T1 and T2, T-AOC and GSH-PX were higher in the SOM group; at T3, they were lower compared to the Non-SOM group.
  • T-AOC and GSH-PX showed similar trends in both groups, increasing until T2 and decreasing at T3, with a more significant decrease in the SOM group.
  • AOPP levels consistently increased in the SOM group; preoperative hypoproteinemia, lack of oral mucosal protective agents, and synchronous chemotherapy were independent risk factors for OM.

Conclusions

  • NPC patients undergoing IMRT exhibit dynamic changes in blood T-AOC, GSH-PX, and AOPP.
  • Persistent elevation of these oxidative stress biomarkers, particularly AOPP, is significantly associated with SOM progression.
  • Oxidative stress imbalance plays a crucial role in the pathogenesis of OM following IMRT.

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